Stem cell transplants may advance ALS treatment by repair of blood-spinal cord barrier

Stem cell transplants may advance ALS treatment by repair of blood-spinal cord barrier Researchers show that bone marrow stem cell transplants helped improve motor functions and nervous system conditions in mice with the disease Amyotrophic Lateral Sclerosis (ALS) by repairing damage to the blood-spinal cord barrier. The researchers say the results of their experiment are…

Prediction of conversion to Alzheimer's disease with longitudinal measures and time-to-event data

Prediction of conversion to Alzheimer’s disease with longitudinal measures and time-to-event data Predicting the timing of Alzheimer’s disease (AD) conversion for individuals with mild cognitive impairment (MCI) can be significantly improved by incorporating longitudinal change information of clinical and neuroimaging markers, in addition to baseline characteristics,  according to projections made by investigators. In a new…

Overall geriatric health during androgen deprivation therapy evaluated

Overall geriatric health during androgen deprivation therapy evaluated Androgen drives many prostate cancers. But the body uses androgen for muscle growth and maintenance, among other functions. An ongoing study evaluates the effects of androgen deprivation therapy not just on patients’ physical function but on global geriatric health, including skills of daily living. Because the study…

Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation

Mechanisms of Action of Probiotics and the Gastrointestinal Microbiota on Gut Motility and Constipation Constipation is a common and burdensome gastrointestinal disorder that may result from altered gastrointestinal motility. The effect of probiotics on constipation has been increasingly investigated in both animal and human studies, showing promising results. However, there is still uncertainty regarding the…

Gut microbes linked to brain structure in people with irritable bowel syndrome

Gut microbes linked to brain structure in people with irritable bowel syndrome Research shows for the first time an association between the gut microbiota and the brain regions involved in the processing of sensory information from their bodies. Also, the researchers gained insight into the connections among childhood trauma, brain development and gut microbiome composition. …

One in five surgical weight-loss patients take prescription opioids seven years after surgery

One in five surgical weight-loss patients take prescription opioids seven years after surgery While the proportion of adults with severe obesity using prescription opioids initially declines in the months after bariatric surgery, it increases within a matter of years, eventually surpassing pre-surgery rates of patients using the potentially addictive pain medications, according to new research. …