EpiCor®, when it was introduced, revolutionized the concept of immune support. Now, we’ve magnified the effects of this powerful immune-boosting supplement by introducing a new, great-tasting liquid formula called Immunotropin™, which features ImmuneCE™, a proprietary blend of the premier immune enhancer EpiCor and a specially derived colostrum fraction that helps “educate” the immune system to target and rapidly respond to invading pathogens.
With the new ImmuneCE blend, EpiCor’s actions become even more profound, helping EpiCor target its efforts by enhancing phagocytosis, the process whereby cells “digest” foreign intruders. ImmuneCE supports phagocytosis and makes cells more susceptible to the action of phagocytes, allowing for a faster response.
Immunity Enhancement Times Two
The delivery of EpiCor, as the key component of the ImmuneCE blend, stimulates the production of immune memory compounds that act as a sort of homing device to more specifically direct the activated natural killer (NK) cells, stimulated by EpiCor, to destroy foreign invaders such as viruses and bacteria. In other words, the components in Immunotropin educate immune cells by teaching them where in the body they need to go to most effectively fight the invading pathogenic organisms.
When EpiCor is blended with the other ingredient in ImmuneCE, it creates a synergistic interaction that promotes even more active immune response, causes faster phagocytosis, supports natural killer cell activation, and protects healthy cells from apoptosis (programmed cell suicide). EpiCor also provides antioxidant benefits that protect live cells from oxidative damage caused by the free radicals produced during the immune responses to the invading pathogens.
In vitro testing suggests this powerful new partner of EpiCor prompts the innate immune system into action while simultaneously encouraging a “smarter” immune response. In order for the human body to recognize an invader as foreign, it must produce antibodies against the invading pathogen. The new fraction contained in ImmuneCE, helps “teach” the body to recognize and target foreign invaders, enhancing the antibody response.
Immune cells known as phagocytes engulf or “eat” the foreign intruders and also educate the immune system as to what is foreign and what is normal. This helps the immune system to respond more rapidly to selectively neutralize pathogens. The “immune memory” enhancing factors contained in ImmuneCE bolsters EpiCor’s actions by priming and targeting the phagocytosis process, thus, making the invading pathogens more susceptible to the aggressive, protective action of the phagocytes.
At this stage in the immune response process, cytokines are secreted to attract other white blood cells to migrate to the tissue area invaded by the foreign organism, in order to destroy it. Preliminary data has documented that the specially derived “immune memory” fraction in ImmuneCE was able to directly induce a number of cytokines that are known to support Th2 responses, which are involved in the humoral or B-lymphocyte immune response.
The next important step in the coordinated immune response involves T-cell and B-cell communication, which leads to natural killer cell activation. T-cells help coordinate this phase of the immune response and help kill identified invaders, while B-cells seek out the targeted pathogenic organisms and produce antibodies against the invading pathogen, which inactivate the invaders and help to repel any future attacks. Both components in the ImmuneCE blend have shown an impressive ability to support activation of natural killer (NK) cells, which kill infected cells and are crucial to holding pathogens at bay until other immune cells can respond.
Taking EpiCor One Step Farther
ImmuneCE demonstrates an impressive ability to enhance the immune response. EpiCor has already been extensively studied for its immune stimulating, protective actions. One of the key ways that EpiCor enhances immunity is through its ability to increase secretory IgA (sIgA) levels. Researchers have demonstrated that subjects given EpiCor have higher levels of total salivary sIgA.1 This indicates that subjects taking EpiCor had the equivalent of an enhanced immunological envelope protecting the membranes in the eyes, nasal passages, mouth and all the exposed membrane surfaces where pathogenic organisms can enter the body.
Studies also have shown that natural killer cells in EpiCor-exposed subjects had a much higher efficiency for killing of pathogen-infected and abnormal cells despite a significant decrease in the natural killer cells’ number, indicating EpiCor increased the natural killer cells’ efficiency. At the same time, subjects exposed to EpiCor experienced a significant inhibition of interferon gamma production and had significantly lower levels of immune complexes, plus produced higher levels of glutathione in their red blood cells, which indicates that EpiCor has anti-inflammatory abilities.2
EpiCor also recently received a Cap-e® bioavailable antioxidants certification. The CAP-e Assay (Cell-based Antioxidant Protection in erythrocytes) analyzes the antioxidant capabilities of natural products inside of cells. In order to claim a product has the potential to slow down or prevent oxidation, its antioxidants must be available at the cellular level.This new CAP-e method evaluates the bioavailability of the antioxidants in a product and documents that the antioxidant molecules have the ability to penetrate living cells and protect them.
Emerging research indicates the other core ingredient in ImmuneCE has actions that are complementary to EpiCor. Cells that were exposed to this ingredient for three minutes experienced enhanced phagocytosis. Furthermore, the “immune-memory” fraction in ImmuneCE activated natural killer cells as indicated by this fraction’s ability to enhance activity of the natural killer cells’ activation marker, known as CD 69. Other actions included its ability to 1) provide protection from oxidative damage in a cell-based antioxidant test; 2) induce the production of the Th2 cytokines IL-4, IL-6 and IL-10, considered to be anti-inflammatory cytokines, that are known to support the humoral immune response toward antibody production and 3) protected live cells from oxidative damage, better than either whole colostrum or whey.
The “immune memory” enhancing factors in ImmuneCE have also been shown to increase the reactive oxygen burst in immune cells known as polymorphic neutrophiles (PMN). The generation of reactive oxygen species (ROS) and free radicals by PMNs is essential to the destruction of the invading, foreign pathogens.
The new liquid Immunotropin formula supports a balanced immune system with a proprietary blend of two powerful immune-enhancing substances. This new formula magnifies the power of EpiCor, producing an even more targeted immune response by supporting phagocytosis, activating natural killer (NK) cell activity and encouraging the production of “immune memory” stimulating factors that help educate the immune system. Individuals who want to build their immunity will appreciate the synergistic effects of the ImmuneCE components in Immunotropin’s liquid formulation.
1. Jensen GS, Patterson KM, Barnes J, et al. A Double-Blind Placebo-Controlled, Randomized Pilot Study: Consumption of a High-Metabolite Immunogen from Yeast Culture has Beneficial Effects on Erythrocyte Health and Mucosal Immune Protection in Healthy Subjects. The Open Nutrition Journal. 2008; 2:68-75.
2. Jensen GS, Hart AN, Schauss AG. An antiinflammatory immunogen from yeast culture induces activation and alters chemokine receptor expression on human natural killer cells and B lymphocytes in vitro. Nutrition Research. 2007 Jun;27(6):327-335.
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