Newly discovered gene variants link innate immunity and Alzheimer's disease

Newly discovered gene variants link innate immunity and Alzheimer’s disease Three new gene variants, found in a genome wide association study of Alzheimer’s disease (AD), point to the brain’s immune cells in the onset of the disorder. These genes encode three proteins that are found in microglia, cells that are part of the brain’s injury…

Source of cell-specific change in Alzheimer's disease

Source of cell-specific change in Alzheimer’s disease Researchers have identified altered expression of a gene called ANK1, which only recently has been associated with memory robbing Alzheimer’s disease, in specific cells in the brain. Following sequencing of each of these cell types, the scientists found that altered ANK1 expression originates in microglia, a type of…

Drug combined with care program better at reducing Alzheimer's symptoms than drug alone

Drug combined with care program better at reducing Alzheimer’s symptoms than drug alone Combining a specific care management program with a commonly-prescribed drug for Alzheimer’s, memantine, multiplies the medication’s ability to improve daily function by about 7.5 times, stalling some of the disease’s most damaging effects, according to new research. With no significant new drug…

Hospitalizations and cognitive decline in older adults

Hospitalizations and cognitive decline in older adults Emergency and urgent hospitalizations are associated with an increased rate of cognitive decline in older adults, report researchers. The results of their study suggest that hospitalization may be a more of a major risk factor for long-term cognitive decline in older adults than previously recognized. Hospitalizations and cognitive…

Bacteria found in Alzheimer's brains

Bacteria found in Alzheimer’s brains Researchers have used DNA sequencing to examine bacteria in post-mortem brains from patients with Alzheimer’s disease. Their findings suggest increased bacterial populations and different proportions of specific bacteria in Alzheimer’s, compared with healthy brains. The findings may support evidence that bacterial infection and inflammation in the brain could contribute to…